Sarne Industries Private Limited

Additional Information:

• Item Code: 4079-68-9
• Production Capacity: 10000
• Delivery Time: 2 day
• Packaging Details: 160 kg HDPE & MS DRUM

Additional Information:

• Item Code: 7447-40-7
• Production Capacity: 500kg
• Delivery Time: 4-5 days
• Packaging Details: 25kg HDPE bag

Overview

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HOBT (1-Hydroxybenzotriazole) monohydrate is a white crystalline powder used in peptide synthesis to suppress racemization and improve reaction efficiency. It's a derivative of benzotriazole and commercially available as a monohydrate, containing about 11.7% water by weight. 
Key points about HOBT monohydrate:
Function:
HOBT acts as a coupling additive, enhancing the efficiency of peptide synthesis and reducing the formation of unwanted racemized products. 
Racemization:
HOBT helps to prevent the formation of the wrong stereoisomer (D-isomer) during peptide synthesis, ensuring the desired L-isomer is produced. 
Peptide synthesis:
It's commonly used in conjunction with other coupling agents like EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) or DCC (dicyclohexylcarbodiimide). 
Other uses:
HOBT can also be used to synthesize amides from carboxylic acids, not just amino acids. 
Anhydrous form:
While HOBT monohydrate is a stable and commercially available form, anhydrous HOBt is known to be explosive. 
Commercial availability:
HOBT monohydrate is a readily available reagent from various chemical suppliers. 
Purity:
HOBT monohydrate is typically available in high purity levels, often 99% or higher. 
Storage:
Proper storage conditions, including keeping it dry and away from heat, are essential to maintain its stability.

• IUPAC Name:
  3-(p-Chloroanilino)-10-(p-chlorophenyl)-2,10-dihydro-2-isopropylimino-phenazine

• Chemical Formula: C₂₇H₂₂Cl₂N₄

• Molecular Weight: 473.39 g/mol

• CAS Number: 2030-63-9

• Drug Class: Riminophenazine dye; antimycobacterial agent

Additional Information:

• Delivery Time: 3-4 days

HOBT, or 1-hydroxybenzotriazole, is a common reagent in organic chemistry, particularly in peptide synthesis. It's a white crystalline powder that is often used as a coupling agent or a racemization inhibitor in peptide coupling reactions. 
Here's a more detailed look at HOBT:
Key Properties and Uses:
CAS Number: 2592-95-2 
Molecular Formula: C6H5N3O 
Appearance: White to off-white powder 
Solubility: Soluble in methanol 
Applications:
Peptide Synthesis: HOBT is widely used to facilitate peptide bond formation and reduce racemization (a side reaction that can lead to undesired products). 
Nucleic Acid Synthesis: HOBT can also be used in the synthesis of nucleic acids. 
Other Reactions: It can also be used in other synthetic reactions where activating a carboxylic acid is beneficial, such as amide formation. 
Mechanism: HOBT works by acting as a nucleophile, forming a reactive ester with the carboxylic acid, which then reacts with the amine to form the desired peptide bond. 
Safety: Anhydrous HOBT is explosive. Commercial HOBT often contains some water, which reduces its explosiveness. It is important to handle HOBT with care, following safety guidelines.

Additional Information:

• Production Capacity: 5000 KG